The second Advances in Nuclear Nonproliferation Technology and Policy Conference is co-sponsored by the American Nuclear Society’s Nuclear Nonproliferation Policy and Fuel Cycle Waste Management Divisions, and taking place in Wilmington, North Carolina from September 23 – 27^th, 2018. This conference seeks to build upon previous ANT topical conferences on nuclear fuel cycle technology, facility safeguards, and nonproliferation technology development. The goal is to stimulate conversation among nuclear science researchers, facilities operators, and policy makers, with technical tracks to include Nuclear Material Control and Accountability, Nonproliferation policy, Analysis and Modeling Methods, Nuclear Nonproliferation and the Fuel Cycle, Challenges in Monitoring the Nuclear Fuel Cycle, Nuclear Facilities and Infrastructure, and Nonproliferation Education and Training. Sessions on these tracks, combined with panel discussions, will provide a venue for discussions on relevant policy and technical needs in nonproliferation.